Hepatectomy

Definition
Purpose
Demographics
Description
Diagnosis/Preparation
Aftercare
Risks
Normal results
Morbidity and mortality rates
Alternatives

Definition

A hepatectomy is the surgical removal of the liver.

Purpose

Hepatectomies are performed to surgically remove tumors from the liver. Most liver cancers start in liver cells called “hepatocytes.” The resulting cancer is called hepatocellular carcinoma or malignant hepatoma.

The type of cancer that can be removed by hepatectomy is called a localized resectable (removable) liver cancer. It is diagnosed as such when there is no evidence that it has spread to the nearby lymph nodesor or to any other parts of the body. Laboratory tests also show that the liver is working well. As part of a multidisciplinary approach, the procedure can offer a chance of long-term remission to patients otherwise guaranteed of having a poor outcome.

Demographics

According to the National Cancer Institute (NCI), liver cancer is relatively uncommon in the United States, although its incidence is rising, mostly as a result of the spread of hepatitis C. However, it is the most common cancer in Africa and Asia, with more than one million new cases diagnosed each year. In the United States, liver cancer and cancer of the bile ducts only account for about 1.5% of all cancer cases. Liver cancer is also associated with cirrhosis in 50–80% of patients.

Description

The extent of the hepatectomy will depend on the size, number, and location of the cancer. It also depends on whether liver function is still adequate. The surgeon may remove a part of the liver that contains the tumor, an entire lobe, or an even larger portion of the liver. In a partial hepatectomy, the surgeon leaves a margin of healthy liver tissue to maintain the functions of the liver. For some patients, liver transplantation may be indicated. In this case, the transplant surgeon performs a total hepatectomy, meaning that the patient’s entire liver is removed, and it is replaced with a healthy liver from a donor. A liver transplant is an option only if the cancer has not spread outside the liver and only if a suitable donor liver can be found that matches the patient. While waiting for an adequate donor, the health care team monitors the patient’s health while providing other therapy.

The surgical procedure is performed under general anesthesia and is quite lengthy, requiring three to four hours. The anesthetized patient is face-up and both arms are drawn away from the body. Surgeons often use a heating pad and wrappings around the arms and legs to reduce losses in body temperature during the surgery. The patient’s abdomen is opened by an incision across the upper abdomen and a midline-extension incision up to the xiphoid (the cartilage located at the bottom middle of the rib cage). The main steps of a partial hepatectomy then proceed as follows:

• Freeing the liver. The first task of the surgeon is to free the liver by cutting the long fibers that wrap it.
• Removal of segments. Once the surgeon has freed the liver, the removal of segments can start. The surgeon must avoid rupturing important blood vessels to avoid a hemorrhage. Two different techniques can be used. The first has the surgeon make a superficial burn with an electric lancet on the surface of the liver to mark the junction between the sections marked for removal and the rest of the liver. He or she cuts out the section, and then tears towards the hepatic parenchyma. It is the difference in resistance between the parenchyma and the vessels that allows the surgeon to identify the presence of a vessel. At this point, he/ she isolates the vessel by removing the surrounding connective tissue, and then clamps it. The surgeon can then cut the vessel, without any danger to the

KEY TERMS

Biopsy— The removal of cells or tissues for examination under a microscope.

Cirrhosis— A type of chronic, progressive liver disease in which liver cells are replaced by scar tissue.

Computed tomagraphy (CT) scan— A series of detailed images of areas inside the body taken at various angles; the images are created on a computer linked to an X-ray machine.

Hepatitis— Disease of the liver causing inflammation. Symptoms include an enlarged liver, fever, nausea, vomiting, abdominal pain, and dark urine.

Hepatocellular carcinoma— The most common type of liver tumor.

Hepatocytes— Liver cells.

Hepatoma— A liver tumor.

Magnetic resonance imaging (MRI)— An imaging technique in which a magnet linked to a computer produces images of areas inside the body.

Parenchyma— The essential elements of an organ, used in anatomical nomenclature as a general term to designate the functional elements of an organ, as distinguished from its framework.

Resectable— Part or all of an organ that can be removed by surgery.

patient. The second technique involves identifying the large vessels feeding the segments to be removed. The surgeon operates first at the level of the veins to free and then clamp the vessels required. Finally, the surgeon can make incisions without worrying about cutting little vessels.

Diagnosis/Preparation

A diagnosis of liver cancer requiring an hepatectomy is obtained with the following procedures:

• physical examination;
• blood tests;
• computed tomagraphy (CT) scan;
• ultrasound test;
• magnetic resonance imaging (MRI);
• angiograms; and
• biopsy.

To prepare a patient for a hepatectomy, clean towels are laid across the patient’s face, along the sides, and across the knees. The anterior portion of the chest, the abdomen, and the lower extremities down to the knees are scrubbed with betadine for 10 minutes. In the event of a patient being allergic to iodine, hibiscrub may be used as an alternative. On completion of the scrub, two sterile towels are used to pat the area dry. The area is then painted with iodine in alcohol, and draping proceeds with side drapes, arm board drapes, top and bottom drapes, and a large steridrape. Three suction devices, one diathermy pencil, and a pair of forceps are placed conveniently around the field.

Aftercare

After an hepatectomy, the healing process takes time; the amount of time required to recover varies from patient to patient. Patients are often uncomfortable for the first few days following surgery and they are usually prescribed pain medication. The treating physician or nurse is available to discuss pain management. Patients usually feel very tired or weak for a while. Also, patients may have diarrhea and a feeling of fullness in the abdomen. The health care team closely monitors the patient for bleeding, infection, liver failure, or other problems requiring immediate medical attention.

After a total hepatectomy followed by a liver transplant, the patient usually stays in the hospital for several weeks. During that time, the health care team constantly monitors how well the patient is accepting the donated liver. The patient is prescribed drugs to prevent the body from rejecting the transplant, which may cause puffiness in the face, high blood pressure, or an increase in body hair.

Risks

Patients with chronic hepatitis and cirrhosis are at high risk when an hepatectomy is performed.

There are always risks with any surgery, but a hepatectomy that removes 25-60% of the liver carries more than the average risk. Pain, bleeding, infection, and/or injury to other areas in the abdomen, as well as death, are potential risks. Other risks include postoperative fevers, pneumonia, and urinary tract infection. Patients who undergo any type of abdominal surgery are also at risk to form blood clots in their legs. These blood clots can break free and move through the heart to the lungs. In the lungs, the blood clot may cause a serious problem called pulmonary embolism, a condition usually treated with blood-thinning medication. In some cases, embolisms can cause death. There are special devices used to keep blood flowing through the legs during surgery to try to prevent clot formation.

WHO PERFORMS THE PROCEDURE AND WHERE IS IT PERFORMED?

A hepatectomy is performed in a hospital setting by a surgeon assisted by a full abdominal surgery team, and possibly an oncologist.

There are also risks that are specific only to liver surgery. During the preoperative evaluation, the treatment team tries to evaluate the patient’s liver so that they can decide what piece can safely be removed. Removal of a portion of the liver may cause the remaining liver to work poorly for a short period of time. The remaining part of the liver will begin to grow back within a few weeks and will improve; however, a patient may develop liver failure.

Normal results

The results of a hepatectomy are considered normal when liver function resumes following a partial hepatectomy, or when the transplant liver starts functioning in the case of a total hepatectomy.

Morbidity and mortality rates

Liver cancer may be cured by hepatectomy, although surgery is the treatment of choice for only a small fraction of patients with localized disease. Prognosis depends on the extent of the cancer and of liver function impairment. According to the NCI, five-year survival rates are very low in the United States, usually less than 10%. Non-Hispanic white men and women have the lowest incidence of and mortality rates for primary liver cancer. Rates in the black and Hispanic populations are roughly twice as high as the rates in whites. The highest incidence rate is in Vietnamese men (41.8 per 100,000), probably reflecting risks associated with the high prevalence of viral hepatitis infections in their homeland. Other Asian-American groups also have liver cancer incidence and mortality rates several times higher than the white population.

Alternatives

There are no alternatives because hepatectomies are performed when liver cancer does not respond to other treatments.

QUESTIONS TO ASK THE DOCTOR

• What tests do I need to determine what type of hepatectomy is required?
• What are the risks involved?
• How many hepatectomies do you perform in a year?
• How long do I need to remain in the hospital?
• How will the hepatectomy affect my normal activities?

Resources

BOOKS

Blumgart, L. H., and Y. Fong. Surgery of the Liver and Biliary Tract, 3rd ed. Philadelphia: Saunders, 2000.

Carr, B. I. Hepatocellular Cancer: Diagnosis and Treatment (Current Clinical Oncology). Totowa, NJ: Humana Press, 2008.

Dionigi, R., and J. Madariaga. New Technologies for Liver Resections. Basel, Switzerland: S. Karger Publishing, 1997.

Martin, P. Liver Transplantation, An Issue of Clinics in Liver Disease. St. Louis, MO: Elsevier Saunders, 2007.

Okita, K. Progress in Hepatocellular Carcinoma Treatment. New York: Springer Verlag, 2000.

PERIODICALS

Ganti, A. L., A. Sardi, and J. Gordon. “Laparoscopic Treatment of Large True Cysts of the Liver and Spleen Is Ineffective.” American Surgeon 68 (November 2002): 1012–1017.

Hemming, A. W., M. S. Cattral, A. I. Reed, et al. “Liver Transplantation for Hepatocellular Carcinoma.” Annals of Surgery 233 (May 2001): 652–659.

Joshi, R. M., P. K. Wagle, A. Darbari, D. G. Chhabra, P. S. Patnaik, and M. P. Katrak. “Hepatic Resection for Benign Liver Pathology—Report of Two Cases.” Indian Journal of Gastroenterology 21(2002): 157–159.

Kammula, U. S., J. F. Buell, D. M. Labow, S. Rosen, J. M. Millis, and M. C. Posner. “Surgical Management of Benign Tumors of the Liver.” International Journal of Gastrointestinal Cancer 30 (2001): 141–146.

Matot, I., O. Scheinin, A. Eid, and O. Jurim. “Epidural Anesthesia and Analgesia in Liver Resection.” Anesthesia and Analgesia 95 (November 2002): 1179–1181.

Zhou, G., W. Cai, H. Li, Y. Zhu, and J. J. Fung. “Experiences Relating to Management of Biliary Tract Complications Following Liver Transplantation in 96 Cases.” Chinese Medical Journal 115 (October 2002): 1533–1537.

OTHER

Cancer Information Service. National Cancer Institute. http://cis.nci.nih.gov (April 21, 2008)

“Liver Cancer.” National Cancer Institute. http://www.nci.nih.gov/cancerinfo/types/liver (April 21,2008).

ORGANIZATIONS

American College of Surgeons, 633 N. Saint Clair St., Chicago, IL, 60611-3211, (312) 202-5000, (800) 621-4111, (312) 202-5001, [email protected], http://www.facs.org.

National Cancer Institute, 6116 Executive Boulevard, Room 3036A, Bethesda, MD, 20892-8322, (800) 422-6237, http://www.cancer.gov.

Society of Toxicology, 1821 Michael Faraday Drive, Suite 300, Reston, VA, 20190, (703) 438-3115, http://www.toxicology.org.

Monique Laberge, Ph.D.

Laura Jean Cataldo, R.N., Ed.D.

Hernia repair, femoral seeFemoral hernia repair

Hernia repair, incisional seeIncisional hernia repair

Hernia repair, inguinal seeInguinal hernia repair

Hernia repair, umbilical seeUmbilical hernia repair

Heterotopic transplant seeLiver transplantation

Hepatectomy

Definition

A hepactectomy is the surgical removal of the liver.

Purpose

Hepatectomies are performed to surgically remove tumors from the liver. Most liver cancers start in liver cells called "hepatocytes." The resulting cancer is called hepatocellular carcinoma or malignant hepatoma.

The type of cancer that can be removed by hepatectomy is called a localized resectable (removable) liver cancer. It is diagnosed as such when there is no evidence that it has spread to the nearby lymph nodes or to any other parts of the body. Laboratory tests also show that the liver is working well. As part of a multidisciplinary approach, the procedure can offer a chance of long-term remission to patients otherwise guaranteed of having a poor outcome.

Demographics

According to the National Cancer Institute (NCI), liver cancer is relatively uncommon in the United States, although its incidence is rising, mostly as a result of the spread of hepatitis C. However, it is the most common cancer in Africa and Asia, with more than one million new cases diagnosed each year. In the United States, liver cancer and cancer of the bile ducts only account for about 1.5% of all cancer cases. Liver cancer is also associated with cirrhosis in 50–80% of patients.

Description

The extent of the hepatectomy will depend on the size, number, and location of the cancer. It also depends on whether liver function is still adequate. The surgeon may remove a part of the liver that contains the tumor, an entire lobe, or an even larger portion of the liver. In a partial hepatectomy, the surgeon leaves a margin of healthy liver tissue to maintain the functions of the liver. For some patients, liver transplantation may be indicated. In this case, the transplant surgeon performs a total hepatectomy, meaning that the patient's entire liver is removed, and it is replaced with a healthy liver from a donor. A liver transplant is an option only if the cancer has not spread outside the liver and only if a suitable donor liver can be found that matches the patient. While waiting for an adequate donor, the health care team monitors the patient's health while providing other therapy.

The surgical procedure is performed under general anesthesia and is quite lengthy, requiring three to four hours. The anesthetized patient is face-up and both arms are drawn away from the body. Surgeons often usea heating pad and wrappings around the arms and legs to reduce losses in body temperature during the surgery. The patient's abdomen is opened by an incision across the upper abdomen and a midline-extension incision up to the xiphoid (the cartilage located at the bottom middle of the rib cage). The main steps of a partial hepatectomy then proceed as follows:

• Freeing the liver. The first task of the surgeon is to free the liver by cutting the long fibers that wrap it.
• Removal of segments. Once the surgeon has freed the liver, the removal of segments can start. The surgeon must avoid rupturing important blood vessels to avoid a hemorrage. Two different techniques can be used. The first has the surgeon make a superficial burn with an electric lancet on the surface of the liver to mark the junction between the sections marked for removal and the rest of the liver. He/she cuts out the section, and then tears towards the hepatic parenchyma. It is the difference in resistance between the parenchyma and the vessels that allows the surgeon to identify the presence of a vessel. At this point, he/she isolates the vessel by removing the surrounding connective tissue, and then clamps it. The surgeon can then cut the vessel, without any danger to the patient. The second technique involves identifying the large vessels feeding the segments to be removed. The surgeon operates first at the level of the veins to free and then clamp the vessels required. Finally, the surgeon can make incisions without worrying about cutting little vessels.

Diagnosis/Preparation

A diagnosis of liver cancer requiring an hepatectomy is obtained with the following procedures:

• physical examination
• blood tests
• computed tomagraphy (CT) scan
• ultrasound test
• magnetic resonance imaging (MRI)
• angiograms
• biopsy

To prepare a patient for a hepactectomy, clean towels are laid across the patient's face, along the sides, and across the knees. The anterior portion of the chest, the abdomen, and the lower extremities down to the knees are scrubbed with betadine for 10 minutes. In the event of a patient being allergic to iodine, hibiscrub may be used as an alternative. On completion of the scrub, two sterile towels are used to pat the area dry. The area is then painted with iodine in alcohol, and draping proceeds with side drapes, arm board drapes, top and bottom drapes, and a large steridrape. Three suction devices, one diathermy pencil, and one forceps are placed conveniently around the field.

Aftercare

After an hepatectomy, the healing process takes time; the amount of time required to recover varies from patient to patient. Patients are often uncomfortable for the first few days following surgery and they are usually prescribed pain medication. The treating physician or nurse is available to discuss pain management . Patients usually feel very tired or weak for a while. Also, patients may have diarrhea and a feeling of fullness in the abdomen. The health care team closely monitors the patient for bleeding, infection, liver failure, or other problems requiring immediate medical attention.

After a total hepatectomy followed by a liver transplant, the patient usually stays in the hospital for several weeks. During that time, the health care team constantly monitors how well the patient is accepting the donated liver. The patient is prescribed drugs to prevent the body from rejecting the transplant, which may cause puffiness in the face, high blood pressure, or an increase in body hair.

Risks

Patients with chronic hepatitis and cirrhosis are at high risk when an hepatectomy is performed.

There are always risks with any surgery, but a hepatectomy that removes 25–60% of the liver carries more than the average risk. Pain, bleeding, infection, and/or injury to other areas in the abdomen, as well as death, are potential risks. Other risks include postoperative fevers, pneumonia, and urinary tract infection. Patients who undergo any type of abdominal surgery are also at risk to form blood clots in their legs. These blood clots can break free and move through the heart to the lungs. In the lungs, the blood clot may cause a serious problem called pulmonary embolism, a condition usually treated with blood-thinning medication. But in some cases, embolisms can cause death. There are special devices used to keep blood flowing through the legs during surgery to try to prevent clot formation.

There are also risks that are specific only to liver surgery. During the preoperative evaluation, the treatment team tries to evaluate the patient's liver so that they can decide what piece can safely be removed. Removal of a portion of the liver may cause the remaining liver to work poorly for a short period of time. The remaining part of the liver will begin to grow back within a few weeks and will improve. However, a patient may develop liver failure.

Normal results

The results of a hepactetomy are considered normal when liver function resumes following a partial hepatectomy, or when the transplant liver starts functioning in the case of a total hepatectomy.

Morbidity and mortality rates

Liver cancer may be cured by hepatectomy, although surgery is the treatment of choice for only a small fraction of patients with localized disease. Prognosis depends on the extent of the cancer and of liver function impairment. According to the NCI, five-year survival rates are very low in the United States, usually less than 10%. Non-Hispanic white men and women have the lowest incidence of and mortality rates for primary liver cancer. Rates in the black and Hispanic populations are roughly twice as high as the rates in whites. The highest incidence rate is in Vietnamese men (41.8 per 100,000), probably reflecting risks associated with the high prevalence of viral hepatitis infections in their homeland. Other Asian-American groups also have liver cancer incidence and mortality rates several times higher than the white population.

Alternatives

There are no alternatives because hepatectomies are performed when liver cancer does not respond to other treatments.

Resources

books

Blumgart, L. H. Surgery of the Liver and Biliary Tract. New York: Churchill Livingstone, 1994.

Carr, B. I. Hepatocellular Cancer: Diagnosis and Treatment (Current Clinical Oncology). Totowa, NJ: Humana Press, 2003.

Dionigi, R. and J. Madariaga. New Technologies for Liver Resections. Basel: S. Karger Publishing, 1997.

Okita, K. Progress in Hepatocellular Carcinoma Treatment. New York: Springer Verlag, 2000.

periodicals

Ganti, A. L., A. Sardi, and J. Gordon. "Laparoscopic Treatment of Large True Cysts of the Liver and Spleen Is Ineffective." American Surgeon, 68 (November 2002): 1012–1017.

Hemming, A. W., D. R. Nelson, and A. I. Reed. "Liver Transplantation for Hepatocellular Carcinoma." Minerva Chirurgica, 57 (October 2002): 575–585.

Joshi, R. M., P. K. Wagle, A. Darbari, D. G. Chhabra, P. S. Patnaik, and M. P. Katrak. "Hepatic Resection for Benign Liver Pathology—Report of Two Cases." Indian Journal of Gastroenterology, 21 (July–August 2003): 157–159.

Kammula, U. S., J. F. Buell, D. M. Labow, S. Rosen, J. M. Millis, and M. C. Posner. "Surgical Management of Benign Tumors of the Liver." International Journal of Gastrointestinal Cancer, 30 (2000): 141–146.

Matot, I., O. Scheinin, A. Eid, and O. Jurim. "Epidural Anesthesia and Analgesia in Liver Resection." Anesthesia and Analgesia, 95 (November 2002): 1179–1181.

Zhou, G., W. Cai, H. Li, Y, Zhu, and J. J. Fung. "Experiences Relating to Management of Biliary Tract Complications Following Liver Transplantation in 96 Cases." Chinese Medical Journal, 115 (October 2002): 1533–1537.

organizations

American College of Surgeons. 633 N. Saint Clair St., Chicago, IL 60611-3211. (312) 202-5000. <www.facs.org>.

National Cancer Institute. Suite 3036A, 6116 Executive Boulevard, MSC8322, Bethesda, MD 20892-8322. (800) 422-6237. <www.cancer.gov/>.

other

Cancer Information Service [cited July 6, 2003]. <http://cis.nci.nih.gov/>.

Liver Cancer Homepage [cited July 6, 2003]. <http://www.nci.nih.gov/cancerinfo/types/liver>.

Monique Laberge, PhD

WHO PERFORMS THE PROCEDURE AND WHERE IS IT PERFORMED?

A hepactectomy is performed in a hospital setting by a surgeon assisted by a full abdominal surgery team, and possibly an oncologist.

QUESTIONS TO ASK THE DOCTOR

• What tests do I need to determine what type of hepatectomy is required?
• What are the risks involved?
• How many hepatectomies do you perform in a year?
• How long do I need to remain in the hospital?
• How will the hepatectomy affect my normal activities?

hepatectomy (hep-ă-tek-tŏmi) n. the operation of removing the liver. partial h. the removal of one or more lobes of the liver; it may be carried out after severe injury or to remove a tumour localized in one part of the liver.