Guadalupe (gwä´dəlōōp´, Span. gwäŧħälōō´pā), town (1990 pop. 2,652), Cáceres prov., W central Spain, in Extremadura. It is noted for its monastery (formerly Hieronymite, now Franciscan) and the shrine of Our Lady of Guadalupe, whose cult was transferred in the 16th cent. to Guadalupe Hidalgo, Mexico. The area is still a pilgrimage center.

Guadalupe (gwäŧħälōō´pā), city (1990 pop. 535,332), Nuevo León state, NE Mexico, on the Santa Catalina River. Its economy is based on agriculture, especially corn, and livestock raising.