Carlisle (kärlīl´, kär´līl), borough (1990 pop. 18,419), seat of Cumberland co., S Pa.; inc. 1782. Its manufactures include electronics and paper, rubber, wood, food, and leather products. In the last conflict (1754–63) of the French and Indian Wars the Forbes (1758) and Bouquet (1763) expeditions were organized there. A munitions depot during the Revolution, Carlisle was a headquarters for Washington during the Whiskey Rebellion in 1794. Molly Pitcher is buried in the Old Graveyard. The borough was a stop on the Underground Railroad and was attacked during the Civil War by Gen. Fitzhugh Lee. Carlisle is the seat of the U.S. Army War College, Dickinson College, and Pennsylvania State Univ. Dickinson School of Law.

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Carlisle, city (1991 pop. 72,006) and district, Cumbria, NW England, near the junction of the Caldew, Eden, and Petteril rivers. The city of Carlisle is an important rail center. Manufactures include textiles, biscuits, and metal products, in addition to a substantial engineering industry. Carlisle also has an important livestock auction. The city's location was formerly strategic; the Roman camp Luguvallium stood there, near Hadrian's Wall. The site figured prominently in the border warfare between the English and the Scots during the Middle Ages. Mary Queen of Scots was imprisoned there in 1568. During the English civil war, parliamentarians captured Carlisle. A technical college is there.