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Keene, city (1990 pop. 22,430), seat of Cheshire co., SW N.H., on the Ashuelot River; settled 1736, inc. as a city 1873. It is a trade and manufacturing center in a farming and resort area. There is printing and publishing, and among Keene's manufactures are electronic equipment and metal and glass products. The city is the seat of Keene State College. To the east is Mt. Monadnock.